• Up to 2 months supply!
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FISETIN - 99% PURITY

Premium FISETIN

Premium FISETIN
Acts as senolytic targeting and eliminating senescent cells
€129,49 (€2,16 per day)
(€0,00 per day) €129,49 (€2,16 per day)

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A key factor in aging is the increase in senescent or "zombie" cells as we age. These cells' buildup is linked to the onset of age-related diseases like diabetes, cancer, and dementia. Fisetin possesses the distinct capability to aid the body in removing these detrimental senescent cells. Regularly consuming MASI Premium Fisetin can combat the buildup of these cells and bolster your body's defenses against age-related conditions such as dementia, Parkinson's, and Alzheimer's.

✓ Eliminates "zombie" cells that contribute to aging

✓ Protects DNA from cellular damage

✓ Reduces bodily inflammation, promoting longevity

  • Fast shipping

    Orders placed before 22:00 are shipped the same day

  • No import duties

    For order outside the EU we got you covered

  • Easy returns

    Money back within the first 30 days

  • Fisetin, a natural flavonoid falling within the flavonol subclass of flavonoids, is a plant pigment abundant in various fruits and vegetables. It shares structural similarities with other flavonols like quercetin and kaempferol. Fisetin can be found in a range of plant-based foods, including strawberries, apples, persimmons, onions, and cucumbers. Its renowned antioxidant properties make it a valuable ally in neutralizing detrimental free radicals within the body, which can otherwise harm cells and contribute to diseases.

    Beyond its antioxidant prowess, fisetin has garnered attention for its potential to support healthy aging, bolster brain health, enhance cardiovascular well-being, and more. Fisetin is readily available as an anti-aging supplement typically offered in the form of a concentrated extract of this natural compound. These longevity supplements are meticulously crafted to deliver a convenient and consistent source of fisetin, enabling individuals to tap into the remarkable health benefits associated with this flavonoid and potentially reverse aging effects.

  • Each serving of 1 capsule contains: 250 mg of pure Fisetin

    Recommended dosage:
    40-50 years - 1 capsule per day;
    50 years and more - 2 capsules per day

  • Fisetin has gained a lot of attention for its function as a senolytic compound. Senolytics are drugs or compounds that selectively target and eliminate senescent ‘zombie’ cells, which are cells that have stopped dividing and are no longer functioning properly. These cells can accumulate in the body with age and contribute to inflammation and age-related diseases.

    Studies have shown that fisetin may help selectively eliminate senescent cells in mice and improve markers of health and longevity. For example, a study published in the journal eBioMedicine found that fisetin supplementation in mice improved physical function, reduced markers of inflammation, and increased lifespan1. Of the 10 flavonoids tested, fisetin was the most potent senolytic.

    In addition, there are several other pathways in which Fisetin may help support healthy aging:

    Chronic inflammation has been linked to a variety of age-related diseases, and fisetin has been shown to help reduce inflammation in the body2–4.

    Fisetin is a powerful antioxidant, which means it helps to neutralise harmful free radicals in the body that can damage cells and contribute to aging. Fisetin functions, at least in part, via interactions with redox signalling pathways, and modulation of the NF-κB, Nrf2, MAPK and PI3K/Akt signalling pathways5,6.

    Fisetin has been shown to help support healthy cellular function and to protect DNA from damage7,8, which can contribute to cellular aging and disease.

    While the exact mechanisms by which fisetin may increase longevity are still being studied, it is clear that this natural flavonoid has a variety of health benefits that support healthy aging.

    Improving health and longevity depends on individual factors such as age, diet, and lifestyle. To maximise the benefits of our supplements, we recommend incorporating them into a comprehensive anti-aging regimen that includes healthy eating, regular exercise, and other lifestyle factors that promote longevity and healthy aging.
  • 1. Yousefzadeh MJ, Zhu Y, McGowan SJ, et al. Fisetin is a senotherapeutic that extends health and lifespan. eBioMedicine. 2018;36:18-28. doi:10.1016/j.ebiom.2018.09.015


    2. Huang W, Li ML, Xia MY, Shao JY. Fisetin-treatment alleviates airway inflammation through inhibition of MyD88/NF-κB signaling pathway. Int J Mol Med. 2018;42(1):208-218. doi:10.3892/ijmm.2018.3582


    3. Molagoda IMN, Jayasingha JACC, Choi YH, Jayasooriya RGPT, Kang CH, Kim GY. Fisetin inhibits lipopolysaccharide-induced inflammatory response by activating β-catenin, leading to a decrease in endotoxic shock. Sci Rep. 2021;11(1):8377. doi:10.1038/s41598-021-87257-0


    4. Sun Y, Qin H, Zhang H, et al. Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. Food Nutr Res. 2021;65. doi:10.29219/fnr.v65.6355


    5. Khan N, Syed DN, Ahmad N, Mukhtar H. Fisetin: A Dietary Antioxidant for Health Promotion. Antioxid Redox Signal. 2013;19(2):151-162. doi:10.1089/ars.2012.4901


    6. Naeimi AF, Alizadeh M. Antioxidant properties of the flavonoid fisetin: An updated review of in vivo and in vitro studies. Trends Food Sci Technol. 2017;70:34-44. doi:10.1016/j.tifs.2017.10.003


    7. Wang T, Lin H, Tu Q, Liu J, Li X. Fisetin Protects DNA Against Oxidative Damage and Its Possible Mechanism. Adv Pharm Bull. 2016;6(2):267. doi:10.15171/apb.2016.037


    8. Park C, Noh JS, Jung Y, et al. Fisetin Attenuated Oxidative Stress-Induced Cellular Damage in ARPE-19 Human Retinal Pigment Epithelial Cells Through Nrf2-Mediated Activation of Heme Oxygenase-1. Front Pharmacol. 2022;13. Accessed March 12, 2023. https://www.frontiersin.org/articles/10.3389/fphar.2022.927898

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MASI is the only line of longevity supplements featuring 100% German materials & engineering.

From source to capsule,
pure transparency.

MASI prioritizes honesty and transparency.
While most companies vaguely claim
"made in [country]" without proof, we openly share our entire process. Ensuring our customers have the full, verifiable story.

  • MASI proudly upholds an unwavering standard by utilizing 100% German raw materials, ensuring zero components are sourced from China. This commitment harnesses the renowned high-quality German engineering, merging meticulous craftsmanship with stringent quality controls. Our dedication to sourcing exclusively within Germany guarantees that each product not only meets but exceeds expectations, offering a synergy of superior engineering and absolute purity, unmatched in the realm of NMN brands.
  • MASI's commitment to superior longevity supplements is rooted in our pharmaceutical-grade German facilities. Each product stands as a testament to unmatched quality and purity, crafted through an advanced enzymatic process, not chemicals, ensuring a pristine formula. Rigorously formulated to meet the highest standards, our supplements are vegan, Halal compliant, gluten-free, kosher-compliant, and allergen-free, reflecting MASI's unwavering dedication to excellence and well-being.
  • Meticulously crafted, our capsules represent the pinnacle of purity and environmental responsibility, sourced from sustainable German pine tree extract. Advanced precision technology ensures consistent dosages for reliable efficacy, while the thoughtfully engineered composition maximizes bioavailability and digestibility, offering a gentle touch on your digestive system. These 100% vegan capsules reflect our commitment to delivering safe, effective health solutions, encapsulating the essence of Germany's botanical treasures in a pristine, contaminant-free process, for a superior, stomach-friendly wellness experience
  • Our products are rigorously third-party tested in Swiss laboratories, including independent verification by an accredited facility, ensuring unmatched standards of purity and safety. Each batch is meticulously analyzed for purity, microbiology—to detect and eliminate harmful microorganisms—and heavy metals like lead, mercury, and cadmium. This comprehensive testing assures the hygiene, purity, and utmost safety of our supplements, reflecting our commitment to delivering contaminant-free, trusted wellness solutions in every pristine batch
  • Ensuring precision in every capsule, our supplements are bottled in a pharmaceutical-grade facility in Germany, renowned for its meticulous standards. This process guarantees exact product amounts in each capsule, upheld by rigorous quality controls for unmatched consistency. This commitment to precision, coupled with our adherence to the highest standards of safety and purity, ensures that every dose delivers the trusted, effective wellness solutions our customers expect
  • Leveraging multiple European facilities, our shipping process ensures exceptionally fast product arrival at minimal costs. With our expansion, new satellite facilities in Australia and the United States further enhance our efficiency, promising speedier delivery, economical rates, and straightforward returns. This robust network guarantees not just swift, but also cost-effective and convenient service, making each order a testament to our commitment to unparalleled customer satisfaction

Extend your years of vibrant living.

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CUSTOMER TESTIMONIALS

EXCELLENT 4.8 based on 31 reviews

Jumping on the longevity supplement train, no regrets

I was a bit skeptical about Fisetin, but after a few weeks, I've noticed a real improvement in how I feel. Definitely worth a try for anyone looking to support their health as they age.

Isla

Verified Buyer

I will only buy high quality supplements if I am going to be ingesting it

I believe you should only put quality products in your body. I did a lot of research, the reason I went with MASI is because they are made in Europe and not china

Seth

Verified Buyer

Just started on supplements, I add this with multi-vitamins and taurine

After hearing so much about Fisetin, I decided to give it a shot. It's been a game-changer for my energy levels and overall sense of wellness. Highly recommend it to my peers.

Lana

Verified Buyer

Skeptical turned believer in longevity supplements

Skepticism faded, now fully on board with the longevity benefits

Ezra

Verified Buyer

Honestly, this longevity stuff? Kinda impressive

Started incorporating Fisetin into my daily routine, and I must say, the results have been pleasantly surprising. I'm feeling more alert and my skin seems to have a new glow.

Sienna

Verified Buyer

So, I gave those longevity pills a shot

So, I gave those longevity pills a shot, and honestly, I'm impressed. I didn't expect much at first, but over the past few weeks, I've noticed a marked improvement in my energy levels and overall mood. It's like I've found a new gear in my day-to-day life. Definitely keeping this in my routine

Beckett

Verified Buyer

“I'm convinced that MASI supplements enhance cellular health and address several aging-related issues. It's a key component of my overall longevity strategy. This strategy includes MASI, regular exercise and a balanced diet, all working together to support a vibrant and healthy life in the years to come.”

Dr.Wolfgang Bucke, Ph.D.,Senior Pharmacist and Board Member

Our lab results speak for themselves. 100% pure Fisetin.

All MASI supplements are rigorously tested in third-party labs in Switzerland. Supplements undergo purity, microbiology and heavy metal tests.

Lab Results

  • We value your trust in our product's quality and would like to provide you with access to its testing results. Below you can view the testing information specific to your batch of product, conducted by a leading testing laboratory in Switzerland.

    Microbiology test result – not detectable.

    Fisetin Microbiology test

    Heavy metals test result – well below the limit values set by European Commission.

    The limit values
    Heavy metal
    lead: 3.0mg/kg
    mercury :2.0mg/kg
    cadmium:0.1mg/kg

    Fisetin Heavy metal test

Eliminate senescent aging cells & increase brain health in as little as 45 days.

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What is Fisetin?

Enhanced Cellular Renewal with Spermidine Tied to Age-Well Benefits

Fisetin, a flavonoid naturally present in fruits like strawberries. Its origin from plants has led to research on its anti-aging applications. One of its key functions is the reduction of senescent cells, which are linked to aging and degenerative diseases. Studies indicate fisetin can extend lifespan in certain models by up to 10%, emphasizing its role in aging.

Additionally, it acts as a potent antioxidant, addressing oxidative stress, a major factor in the aging process. It also supports brain health, potentially reducing the incidence of neurodegenerative conditions. David Sinclair, a renowned longevity scientist, incorporates 500mg of fisetin into his supplement regimen, highlighting its importance in promoting healthy aging. Fisetin's multifaceted approach to aging, from senescent cells also known as "zombie cells" that no longer divide but accumulate as we age, causing various health issues. It's like a cleanup crew, removing these cells to promote healthier aging.

Fisetin

Less age-related worries. More life.

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personalized MASI anti-aging plan

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Who should be taking anti-aging supplements?

  • Age 30-45, notices the body's evolving needs, observing the emergence of wrinkles and fine lines, sensing emotional reactions to aging and experiencing a decline in energy and memory.
  • Science-based thinkiners, motivated by scientific research and discoveries, fascinated by the pursuit of graceful aging and longevity, dedicated to investing time and resources in anti-aging strategies.
  • Advocates for healthy lifestyle choices, strongly focused on a nutritious diet and regular exercise, committed to proactive change and the use of supplements for well-being.
  • Age 45-80, visible signs of aging, decline in skin elasticity and firmness, increases physical fatigue, memory lapses, mild to extreme cognitive decline, pursuing enhancements in the essential years, aspiring for overall well-being.

Core features of our products

Shop our bundles

Wellness Regimen

A carefully curated starter pack features NMN and Resveratrol, two powerhouse supplements known for anti-aging properties. NMN a NAD+ booster and resveratrol, a potent antioxidant.

€265,99

Health Apex

Step up your health with NMN and Spermidine, combined to deliver advanced anti-aging benefits. NMN, enhances cellular vitality, while Spermidine promotes cellular renewal and longevity.

€305,99

Vitality Boost

A powerhouse of rejuvenation, thoughtfully combining NMN, Spermidine, and Fisetin to amplify your anti-aging efforts. NMN directly boosting NAD+, remaining as the foundation, followed by Spermidine enhancing this effect by promoting cellular autophagy, the body's rejuvenating process and Fisetin adds to this dynamic trio by targeting age-related cellular inflammation and stress.

€439,99

Longevity Legacy

The Longevity Legacy bundle is the pinnacle of anti-aging excellence, featuring a potent combination of all four MASI supplements. This quartet represents the ultimate in longevity science. NMN boosts vital cellular energy and metabolism, while Resveratrol, a renowned antioxidant, combats oxidative stress. Spermidine contributes by enhancing cellular autophagy and Fisetin completes this powerful ensemble by targeting age-related cellular inflammation Together, these supplements offer an unparalleled, comprehensive approach to aging, ensuring not just extended years, but a life enriched with vitality and wellness. The "Longevity Legacy" bundle is the epitome of a holistic, advanced anti-aging solution.

€525,99

Frequently Asked Questions

  • Fisetin is a flavonoid compound with antioxidant properties, found in various fruits and vegetables.
  • Fisetin works by reducing oxidative stress and inflammation, potentially slowing down the aging process at the cellular level.
  • Yes, Fisetin has shown positive data for having anti-aging effects by promoting cellular health and longevity.
  • The main benefits include antioxidant effects, potential improvement in brain health, and support in cellular function and longevity.
  • The optimal daily dosage of Fisetin 250mg for ages 50 and under and 500mg for ages 50 and over.
  • Fisetin is considered safe, but high doses might cause side effects; it's best to consult with a healthcare provider.
  • Fisetin may interact with certain medications; it's important to always do research and consult a healthcare provider when mixing medications.
  • Foods rich in Fisetin include strawberries, apples, persimmons, and onions.
  • The time to notice effects can vary; consistent, long-term use is generally needed to observe benefits. Studies have shown results in as little as 2 weeks.
  • Fisetin is safe for most people, but pregnant or nursing individuals and those with health conditions should consult a doctor first.